Welcome to the UK Centre for Mammalian Synthetic Biology Research. Our aim is to pioneer the development of the underpinning tools and technologies needed to implement engineering principles and realise the full potential of synthetic biology in mammalian systems. The BBSRC/EPSRC/MRC funded Centre builds on more than seven years of productive multidisciplinary research in Edinburgh in synthetic and systems biology, extending its reach to embrace our world-leading expertise in cell biology, epigenetics and stem cell biology, and in human and veterinary medicine. We have an ambitious plan to build expertise in cell engineering tool generation, whole-cell modelling, computer-assisted design and construction of DNA and high-throughput phenotyping to enable synthetic biology in mammalian systems for multiple applications. In this way we will not only advance basic understanding of mammalian biology but also generate tools and technologies for near-term commercial exploitation in areas such as the pharmaceutical and drug testing industries, diagnostics, novel therapeutics, production of protein based drugs and also programming stem cell development and differentiation for regenerative medicine applications. Underpinning this will be the development of standards for mammalian synthetic biology and taking the concept of Responsible Research and Innovation in new directions to include the use of strategic mapping methodologies and new approaches to engagement informed by speculative design.
Prof Susan Rosser, Centre Director