Realising the potential of synthetic biology for health

Learning by Building

We can apply the synthetic and systems biology tools that we develop to (re)build biological systems and so gain deeper understanding of Nature. This will enable is to construct more sophisticated platforms to accelerate biomedical research and development.

Creating Novel Biosensors

We will engineer cell lines to contain synthetic circuits to permit complex information processing such as the ability to count events (e.g. numbers of cell divisions) or to create memory devices and logic gates. These can be applied to a wide range of cells (including patient-derived stem cells) to create value-added cellular assays for improving the drug discovery process.

Regenerative Medicine

The full potential of stem cells, naïve undifferentiated cells of the body or embryo, lies only in our ability to control and direct their differentiation down specific developmental pathways. We will use the synthetic biology tools developed to engineer cells to differentiate, or die, on specific triggers.

We can also apply synthetic biology for tissue engineering – so-called synthetic morphology – creating three-dimensional assays more suited for drug safety testing or for human regenerative medicine.